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Silicosis is a progressive lung disease resulting from the inhalation of respirable crystalline silica. Lung transplantation is the only treatment for end-stage silicosis. The aim of this study was to analyze the survival experience following lung transplantation among patients with silicosis.
We reviewed data for all patients who underwent lung transplantation for silicosis and a matched group undergoing lung transplantation for idiopathic pulmonary fibrosis (IPF) at a single medical center between March 2006 and the end of December 2013. Survival was followed through 2015.
A total of 17 lung transplantations were performed for silicosis among 342 lung transplantations (4.9%) during the study period. We observed non-statistically significant survival advantage (hazard ratio 0.6; 95%CI 0.24–1.55) for those undergoing lung transplantation for silicosis relative to IPF patients undergoing lung transplantation during the same period.
Within the limits of a small sample, survival in silicosis patients following lung transplantation was not reduced compared to IPF. Am. J. Ind. Med. 9999:1–7, 2016. © 2016 Wiley Periodicals, Inc.
Underreporting in the nation's primary source of non-fatal occupational injury and illness data are well documented, but worker-level characteristics of unreported cases have not been fully explored.
Bureau of Labor Statistics’ Survey of Occupational Injuries and Illnesses (SOII) data were linked to Washington workers’ compensation claims to identify injury and claim characteristics associated with unreported cases. Workers’ compensation administrative date data were used to characterize timing of disability and SOII case eligibility.
Based on claim date data, one in five lost time claims with an injury date in the survey year were likely ineligible for SOII case reporting during the survey year. Among SOII-eligible claims, those involving sprains or strains, employer protests, and those not eligible for work disability payments until months after the initial injury were least likely to be reported in SOII.
SOII case capture is limited both by its cross sectional survey design and employer underreporting. Am. J. Ind. Med. 9999:XX–XX, © 2016 Wiley Periodicals, Inc.
Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non-smokers with adenocarcinoma.
Methods Mutations in the EGFR gene were investigated using next-generation sequencing.
We report the presence of EGFR exon point mutations in the pulmonary adenocarcinomas of three never-smokers occupationally exposed to asbestos.
The role of asbestos as a possible cause of EGFR mutagenesis requires further investigation. Am. J. Ind. Med. © 2017 Wiley Periodicals, Inc.