Κυριακή 27 Φεβρουαρίου 2022

Precise fabrication of porous polymer frameworks using rigid polyisocyanides as building blocks: from structural regulation to efficient iodine capture

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Chem Sci. 2022 Jan 12;13(4):1111-1118. doi: 10.1039/d1sc05361b. eCollection 2022 Jan 26.

ABSTRACT

Porous materials have recently attracted much attention owing to their fascinating structures and broad applications. Moreover, exploring novel porous polymers affording the efficient capture of iodine is of significant interest. In contrast to the reported porous polymers fabricated with small molecular blocks, we herein report the preparation of porous polymer frameworks using rigid polyisocyanides as building blocks. First, tetrahedral four-arm star polyisocyanides with predictable molecular weight and low dispersity were synthesized; the chain-ends of the rigid polyisocyanide blocks were then crosslinked, yielding well-defined porous organic frameworks with a designed pore size and narrow distribution. Polymers of appropriate pore size were observed to efficiently capture radioactive iodine in both aqueous and vapor phases. More than 98% of iodine could be captured within 1 minute from a saturated aqueous solution (capacity of up to 3.2 g g-1), and an adsorption capacity of up to 574 wt% of iodine in vapor was measured within 4 hours. Moreover, the polymers could be recovered and recycled for iodine capture for at least six times, while maintaining high performance.

PMID:35211277 | PMC:PMC8790772 | DOI:10.1039/d1sc05361b

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L-Thyroxine Improves Vestibular Compensation in a Rat Model of Acute Peripheral Vestibulopathy: Cellular and Behavioral Aspects

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Cells. 2022 Feb 16;11(4):684. doi: 10.3390/cells11040684.

ABSTRACT

Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Thyroid hormone receptors (TRα and TRβ) and type II iodothyronine deiodinase (DIO2) were present in the vestibular nuclei (VN), supporting a local action of L-T4. We confirmed the T4-induced metabolic effects by demonstrating an increase in the number of cytochrome oxidase-labeled neurons in the VN three days after the lesion. L-T4 treatment modulated glial reaction by decreasing both microglia and oligodendrocytes in the deafferen ted VN three days after UVN and increased cell proliferation. Survival of newly generated cells in the deafferented vestibular nuclei was not affected, but microglial rather than neuronal differentiation was favored by L-T4 treatment.

PMID:35203333 | DOI:10.3390/cells11040684

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Anatomical features of the iliocapsularis muscle: a dissection study

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Surg Radiol Anat. 2022 Feb 26. doi: 10.1007/s00276-022-02905-y. Online ahead of print.

ABSTRACT

PURPOSE: Iliocapsularis (IC) overlies the anteromedial hip capsule and is an important landmark in anterior approaches to hip arthroplasty. Previously believed to be part of iliacus, few publications describe the prevalence, attachments, fibre direction, blood supply, innervation, and size of IC. This study was aimed to determine these anatomical features using embalmed bodies and whether they vary between sides, sex, and age.

METHODS: Thirty-eight formalin-fixed adult bodies were dissected and the prevalence, presence of a connective tissue raphe, attachments, fibre direction, blood supply, and innervation, were documented. Length and width were measured, and significant differences were investigated with t tests.

RESULTS: Iliocapsularis was present in all bodies examined, originating from the inferior border of the anterior inferior iliac spine, and inserting 20 mm distal to the lesser trochanter in 54 muscles (71%). Iliocapsularis was supplied by a thin branch from the femoral nerve and by branches of the lateral circumflex femoral and deep femoral arteries and veins. Muscle fibre direction was from superolateral to inferomedial. Mean length was 116.8 ± 11.2 mm and width was 12.8 ± 3.1 mm, with no significant differences between sides, sex, and age.

CONCLUSION: This was the first study to document the venous drainage and compare the di mensions with sides, sex, and age, using adult bodies. However, the true function of IC is still unknown. Iliocapsularis is a constant muscle, distinct from iliacus, which is relevant to orthopaedic surgeons and physical rehabilitation specialists, particularly for postoperative patient care.

PMID:35218407 | DOI:10.1007/s00276-022-02905-y

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Dendritic cells in reflectance confocal microscopy is a clue for early melanoma diagnosis in extrafacial flat pigmented melanocytic lesions

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Abstract

Background

Differential diagnosis of extrafacial flat pigmented lesions with dermoscopic reticular and/or homogeneous pattern is challenging. Dendritic cells upon reflectance confocal microscopy (RCM) still represent a pitfall.

Objective

To determine the role of dendritic cells upon RCM in the epidermis and dermo-epidermal junction (DEJ), together with common RCM features for melanoma and nevi, in dermoscopically equivocal extrafacial flat pigmented lesions.

Methods

A retrospective evaluation of RCM images of melanocytic extrafacial flat pigmented lesions with reticular and/or homogeneous dermoscopic pattern and with histopathological diagnosis, was performed. A multivariate model of RCM features was used to obtain a score of independent risk factors.

Results

A total of 698 lesions were included. Increasing patient age, epidermal dendritic cells, many dendritic cells in the DEJ (>30%), and many (>5/mm2) round atypical cells were independent risk factors for melanoma. Edged papillae and melanophages were indicative of nevus. A score based on these features was developed to assist in melanoma differential diagnosis.

Conclusion

The RCM observation of abundant (>30%) dendritic cells in the DEJ is highly suggestive of malignity. This independent risk factor should also be considered for improved differential diagnosis of extrafacial melanoma.

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Can cystic lesions of the jaws be considered as the cause of mandibular asymmetry?

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Med Oral Patol Oral Cir Bucal. 2022 Mar 1;27(2):e159-e163. doi: 10.4317/medoral.25134.

ABSTRACT

BACKGROUND: The aim of this study is to investigate the presence of condylar and ramal asymmetry in patients with a cyst larger than 10 mm in the maxilla or mandible.

MATERIAL AND METHODS: Condylar and ramal asymmetry index measurements of 47 patients (mean age: 28.85 ± 15.348) in the study group and 40 patients in the control group (mean age: 33.73 ± 13.095) were performed using panoramic radiographs. The study group consists of patients with cysts larger than 10 mm in diameter in the maxilla or mandible. The control group consisted of patients with no radiolucent lesions and no history of trauma. The possible statistical difference between the groups was evaluated by the Mann-Whitney U test.

RESULTS: No statistically significant difference was observed in asymmetry indices according to gender and the jaw (maxilla or mandible) in which the cyst was located. However, it was determined that CAI and RAI values were statistically significantly different between the study and control groups (p = 0.047 and p = 0.016, respectively).

CONCLUSIONS: The presence of intraosseous cysts larger than 10 mm in the jaws was found to be associated with condylar and ramal asymmetry.

PMID:35218644 | DOI:10.4317/medoral.25134

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MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study

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Med Oral Patol Oral Cir Bucal. 2022 Mar 1;27(2):e164-e173. doi: 10.4317/medoral.25138.

ABSTRACT

BACKGROUND: Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutSα (hMSH2-hMSH6) and MutSβ (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival.

MATERIAL AND METHODS: Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3- hMSH6 expression, respectively.

RESULTS: hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed.

CONCLUSIONS: Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT.

PMID:35218645 | DOI:10.4317/medoral.25138

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Παρασκευή 25 Φεβρουαρίου 2022

"κλιματική αλλαγή" - νέα αποτελέσματα

[PDF] Χωροχρονική διερεύνηση των μεταβολών της εδαφοκάλυψης με χρήση Γεωγραφικών Συστημάτων στην περιοχή Παρνασσού-Γκιώνας

Δ Μαντζιούτα - 2022
… Η κλιματική αλλαγή που βρίσκεται σε εξέλιξη τις τελευταίες δεκαετίες σε συνδυασμό
με τις συνεχείς αλλαγές σε βιοτικό, κοινωνικό, πολιτικό και οικονομικό επίπεδο
επηρεάζουν δραστικά τη μεταβολή της εδαφοκάλυψης. Η παρακολούθηση και μελέτη …
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[PDF] Η Διεθνής Υπηρεσία Ενέργειας (International Energy Agency) και η συμβολή της στην παγκόσμια ενεργειακή ασφάλεια

Ι Καψάλη - 2022
… Η ασφάλεια των υποδομών ως πτυχή της έννοιας της ενεργειακής ασφάλειας
καταδεικνύει τον αναπόφευκτο συσχετισμό της με την κλιματική αλλαγή, η οποία την
επηρεάζει άμεσα δεδομένου ότι οι ενεργειακές υποδομές είναι ευαίσθητες στην …
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[PDF] Εκπαίδευση για την αειφορία. Η περίπτωση του αειφόρου σχολείου. Στόχοι, προοπτική, στρατηγική στην εφαρμογή του στο νηπιαγωγείο

Β Δεμίρη - 2022
… Η περιβαλλοντική κρίση συμπίπτει με την οικονομική ύφεση και εκεί τοποθετείται ο
πρόεδρος της Βενεζουέλας, Hugo Chavez, λέγοντας στη σύνοδο για την κλιματική
αλλαγή το 2009 πως «Αν το κλίμα ήταν Τράπεζα θα το είχατε ήδη σώσει». Προφανώς …
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[PDF] Εφαρμογή της θεώρησης της Γαλάζιας Ανάπτυξης και της διαδικασίας της ολοκληρωμένης διαχείρισης παράκτιας ζώνης με στόχο την αξιοποίηση των …

Ι Ηλιοπούλου - 2022
… Η βιωσιμότητα των ωκεανών, η οποία συνδέεται άρρηκτα με την κλιματική αλλαγή
αναγνωρίζεται σήμερα ευρέως ως σημαντική παγκόσμια πρόκληση. Ο αυξανόμενος
ανταγωνισμός για τη χρησιμοποίηση του θαλάσσιου χώρου και οι σωρευτικές …
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Τα δημοφιλή αποτελέσματα εμφανίζονται στο πάνω μέρος της ενότητας και τα άλλα αποτελέσματα στο κάτω μέρος.



 

[PDF] Ενεργειακή αναβάθμιση τμήματος ξενοδοχειακής μονάδας

Ε Κυρίτσης - 2022
… Οι διεργασίες αυτές έχουν συμβάλλει σημαντικά στην επιτελούμενη κλιματική
αλλαγή ενδείξεις της οποίας είναι οι ακόλουθες : … Σκοπός της συμφωνίας είναι η
μείωση των εκπομπών αερίων του θερμοκηπίου τα οποία συμβάλλουν στην …
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[PDF] Οι ενεργειακές επιλογές της Κυπριακής Δημοκρατίας

Ζ Λιάτσου - 2022
… 64 Η Συμφωνία των Παρισίων για την κλιματική αλλαγή έχει υπογραφεί και
κυρωθεί από όλα τα κράτη μέλη και αντανακλά τη δέσμευση εκ μέρους αυτών για την
ανάπτυξη κλιματικά ουδέτερης οικονομίας και κοινωνίας μέχρι το 2050. Πρόκειται για …
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[PDF] Ο ηγεμονικός ρόλος του Hνωμένου Bασιλείου στον 21ο αιώνα: από το brexit στην υψηλή στρατηγική του global britain

Α Παντικάκης - 2021
Η παρούσα διατριβή αποτέλεσε μια προσπάθεια εξέτασης του ηγεμονικού ρόλου του
Ηνωμένου Βασιλείου στον 21ο αιώνα, ξεκινώντας από το BREXIT και καταλήγοντας
στη διατύπωση της υψηλής στρατηγικής του Global Britain. Στην παρούσα μελέτη …
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Το μήνυμα αυτό στάλθηκε από το Google Scholar επειδή ακολουθείτε νέα αποτελέσματα σχετικά με το θέμα ["κλιματική αλλαγή"].