Δευτέρα 31 Ιανουαρίου 2022

Varicella post-exposure management for pediatric oncology patients

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Bull Cancer. 2022 Jan 26:S0007-4551(22)00004-2. doi: 10.1016/j.bulcan.2021.11.016. Online ahead of print.

ABSTRACT

INTRODUCTION: The objective was to evaluate health care providers' (HCP) adherence to and efficacy of varicella post-exposure prophylaxis (PEP) recommendations. It was an observational, prospective, multicenter study set in Ile-de-France, France.

METHODS: All children under 18 with a cancer diagnosis, currently or within 3months of receiving cancer treatment, regardless of varicella zoster virus (VZV) serostatus or previous personal history of varicella, were eligible. Study participants with significant exposure were reviewed prospectively for PEP indications. Main outcome measures were the percentage of exposure situations for which HCP were guideline-compliant, the proportion of available VZV serostatuses and the incidence of breakthrough varicella after different PEP approaches.

RESULTS: A total of 51 patie nts from 15 centers were enrolled after 52 exposure episodes. Median age at exposure was 5 years (range, 1-15). Exposure within the household led to 38% of episodes. Prophylactic treatment consisted in specific anti-VZV immunoglobulins (V-ZIG) (n=19) or in oral aciclovir (n=15). No prophylactic treatment was given for 18 patients (in compliance, n=16). In compliance with guidelines, 17 patients received V-ZIG, 11 did not develop varicella (65%, [95% CI, 39-90%]); 15 received aciclovir, 13 did not develop varicella (87%, [95% CI, 67-100%]). Breakthrough varicella occurred in 11 patients, with simple clinical course in all cases; in 8/47 (17%) episodes when PEP was guideline-compliant versus 3/5 (60%) when not.

DISCUSSION: Recommendations have been respected and are efficient. PEP needs to be standardized and a study carried out to define the optimal approach. Anti-VZV immunization of seronegative family members should be encouraged.

PMID:35093244 | DOI:10.1016/j.bulcan.2021.11.016

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Computed tomography-assessed variations of the carotid sinus

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Surg Radiol Anat. 2022 Jan 30. doi: 10.1007/s00276-021-02871-x. Online ahead of print.

ABSTRACT

PURPOSE AND BACKGROUND: Previous studies have identified variations regarding the morphology and location of the carotid sinus, a phenomenon still not commonly approached or studied on computed tomography angiography (CTA). Detailed characterization of the carotid sinus was performed on CTAs, determining its position, diameter and length.

METHODS: The study group included 43 patients with disease-free carotid trunks subjected to cervical CTA. We measured the terminal caliber of the common carotid artery (CCA), as well as the calibers of the internal (ICA) and external carotid arteries (ECA) at their origin. The diameters were correlated with the location and the shape of the carotid sinus. We also measured the length of the sinus dilatation (carotid bulb), in regard to its location on the terminal branches of the common carotid artery.

RESULTS: Mean diameters of the studied arteries were 7.39 ± 1.04 mm for the CCA, 6.71 ± 1.49 mm for the ICA and, respectively, 4.27 ± 0.75 mm for the ECA. The classical position of the carotid sinus was seen in 80% of cases, the rest being considered anatomical variants. The length of the carotid bulb on the ICA was 9.99 ± 2.22 mm, showing variability between genders.

CONCLUSIONS: The carotid sinus does not always extend to the ICA, presenting different distribution patterns that might be relevant in sinu s pathology from a clinical point of view, respectively from a surgical point of view during invasive or minimally invasive interventions on the carotid axis.

PMID:35094129 | DOI:10.1007/s00276-021-02871-x

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Thyroid Disease in Pregnancy: A Touch of Clarity

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Thyroid, Ahead of Print.
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Κυριακή 30 Ιανουαρίου 2022

A new classification of maxillary defect and simultaneous accurate reconstruction

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Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Jan 7;57(1):8-14. doi: 10.3760/cma.j.cn115330-20210724-00484.

ABSTRACT

Objective: To select the preferred flaps for the reconstruction of different maxillary defects and to propose a new classification of maxillary defects. Methods: A total of 219 patients (136 males and 83 females) underwent the simultaneous reconstruction of maxillary defects in the Beijing Tongren Hospital, Capital Medical University, between January 2005 and December 2018 were reviewed. Age ranged from 16 to 78 years. Based on the proposed new classification of the maxillary defects, 22 patients with class Ⅰ defects (inferior maxillectomy), 44 patients with class Ⅱ defects (supperior maxillectomy), 132 patients with class Ⅲ defects (total maxillectomy) and 21 patients with class Ⅳ defects (extensive maxillectomy) were enrolled. Survival rate, functional and aesthetic outcomes of flaps were ev aluated. Survival analysis was performed in 169 patients with malignant tumor, Kaplan-Meier method was used to calculate the survival rate, and Log-rank method was used to compare the difference of survival rate in each group. Results: A total of 234 repairs for maxillary defects were performed in 219 patients. Fibula flaps were used in 4/13 of class Ⅰ defects; temporal muscle flaps (11/24, 45.8%) and anterolateral thigh flaps (6/24, 25.0%) used in class Ⅱ defects; temporal muscle flaps (71/128, 55.5%), anterolateral thigh flaps (6/24, 25.0%) and fibula flaps (12/128, 9.4%) used in class Ⅲ defects; and anterolateral thigh flaps (8/20, 40.0%) and rectus abdominis flaps (8/20, 40.0%) used in class Ⅳ defects. The success rate of local pedicled flaps was 95.6% (109/114) and that of free flaps was 95.8% (115/120). Thrombosis(10/234,4.3%) was a main reason for repair failure. Among the followed-up 88 patients, swallowing and speech functions recovered, 82 (93.2%) of them we re satisfied with appearance, and 75 (85.2%) were satisfied with visual field. The 3-year and 5-year overall survival rates were 66.5% and 63.6%, and the 3-year and 5-year disease-free survival rates were 57.1% and 46.2%, respectively, in the 169 patients with malignant tumors. Conclusion: A new classification of maxillary defects is proposed, on which suitable flaps are selected to offer patients good functional and aesthetic outcomes and high quality of life.

PMID:35090203 | DOI:10.3760/cma.j.cn115330-20210724-00484

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Place of Linacs in extracranial stereotactic radiotherapy: Are they now equivalent to Cyberknife®?

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Bull Cancer. 2022 Jan 25:S0007-4551(22)00003-0. doi: 10.1016/j.bulcan.2021.10.008. Online ahead of print.

ABSTRACT

Extracranial stereotactic radiotherapy has developed recently, since the years 1990-2000. Devices specifically dedicated to this type of treatment were then developed and shared the favors of radiation oncologists: Tomotherapy® and especially Cyberknife®, which offered the advantage of "tracking" with the possibility of real time motion correction, allowing an increase in the precision of targeting volumes. Recently, the latest generations of linear accelerators (Linac) have been developed, integrating much higher dose rates, an improved ballistic precision with a very short treatment duration time and the possibility of real time motion management (with notably the possibility of adaptive radiotherapy in real time with the development of "MLC tracking"). So are Linacs able to perform equivalent (not inferior) extracrani al stereotactic radiotherapy treatments to those with Cyberknife®, the historical gold standard in this field? This article presents a comparison of these two treatment devices, by successively considering dose distributions in the irradiated volume, distant received doses from this volume (including the "integral dose"), problems linked to the duration of the sessions and those linked to motion management.

PMID:35090720 | DOI:10.1016/j.bulcan.2021.10.008

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The importance of systemic immune-inflammation index in obstructive sleep apnea syndrome

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Eur Arch Otorhinolaryngol. 2022 Jan 29. doi: 10.1007/s00405-021-07227-0. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aims to explore the importance of systemic immune-inflammation index (SII) in patients diagnosed with obstructive sleep apnea (OSA).

MATERIALS AND METHOD: In this study planned as a retrospective cohort, the files of the patients who presented with sleep apnea/snoring complaint between 10.01.2017 and 10.01.2021 and underwent polysomnography (PSG) and complete blood count analyses were reviewed. PSG findings (age, sex, body mass index (BMI), apnea-hypopnea index (AHI), mean oxygen saturation) were compared with SII in 194 patients meeting study eligibility criteria.

RESULTS: Patients included in this study were divided into 4 groups by AHI value. Statistical difference was detected between the groups in terms of age, sex, body mass index (BMI), and mean oxygen saturation (p < 0.05). There is an ap proximately 30% positive statistically significant correlation between the severity of OSA and SII (p < 0.001). As for the mean SII values of the AHI groups, it was observed that the more severe AHI is, the higher the mean SII value is. The correlation between SII and the severity of OSA was found to be more significant than the correlation with neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR).

CONCLUSION: There is a significant correlation between SII and the severity of OSA. This correlation is stronger compared to NLR and PLR. SII can be used to demonstrate the chronic systemic inflammation observed in OSA patients, and can be utilized as a simple and inexpensive biomarker as it can be easily calculated from the parameters present in routine blood analyses.

PMID:35091830 | DOI:10.1007/s00405-021-07227-0

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Bereavement Practices Among Head and Neck Cancer Surgeons

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Objectives

Head and neck cancer surgeons frequently interact with dying patients with advanced disease and their families, but little is known about their bereavement practices after a patient's death. The aim of this study is to elucidate the frequency of common bereavement practices, cited barriers to bereavement, and predictive physician factors that lead to an increase in bereavement practices among head and neck cancer surgeons.

Methods

A 20-item survey was sent to 827 active surgeons of the American Head and Neck Society. Approval was obtained and the survey was distributed through the American Head and Neck Society. Demographics, frequency of common bereavement practices, empathy, and barriers were assessed. Multiple linear regression was performed to determine physician factors associated with more frequent bereavement follow-up.

Results

There were 156 respondents (18.9% response rate). Overall, surgeons were more likely to usually/always call (48.5%) or send a letter (42.4%) compared with other practices such as attending funerals (0%), offering family meetings (18.6%), or referring family members to counseling (7.7%). Many barriers were cited as being at least somewhat important: being unaware about a patient's death (67.3%) was the most cited, whereas 51.3% cited a lack of mentorship/training in this area. Scoring higher on empathy questions (P ≤ .001) was associated with more frequent surgeon bereavement follow-up with the family of deceased patients.

Conclusion

There is substantial practice variation among surgeons suggesting a lack of consensus on their roles in bereavement follow-up. Having higher empathy was predictive of higher engagement.

Level of Evidence

NA Laryngoscope, 2022

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Diagnostic accuracy of conventional oral examination for detecting oral cavity cancer and potentially malignant disorders in patients with clinically evident oral lesions: Systematic review and meta‐analysis

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Abstract

This systematic review evaluates the diagnostic accuracy of conventional oral examination (COE) versus incisional or excisional biopsy for the diagnosis of malignant and/or dysplastic lesions in patients with clinically evident lesions. Searches were conducted across five electronic databases from inception to January 2020. Meta-analyses were undertaken, where appropriate. Among 18 included studies, 14 studies were included in the meta-analysis, giving summary estimates for COE of 71% sensitivity and 85% specificity for the diagnosis of dysplastic and/or malignant lesions. The pooled diagnostic accuracy of identifying malignant-only lesions was reported in seven studies, giving a pooled estimate of 88% sensitivity and 81% specificity. Diagnostic accuracy of different types of dental/medical professionals in identifying dysplastic or malignant lesions gave varying estimates of sensitivity and specificity across three studies. Further research is needed to improve the diagnostic acc uracy of COE for early detection of dysplastic and malignant oral lesions.

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Παρασκευή 28 Ιανουαρίου 2022

"Περιβαλλοντικά προβλήματα" - νέα αποτελέσματα

[PDF] The four seasons: Teaching scenario for pupils of the 1st Grade of primary school in distance education

Μ Χρήστου - Διεθνές Συνέδριο για την Ανοικτή & εξ Αποστάσεως …, 2022
… Επίσης, μέσα από τις δραστηριότητες επεξεργασίας των έργων τέχνης οι μαθητές
άρχισαν να συνειδητοποιήσουν ότι συγκεκριμένες ανθρώπινες δραστηριότητες
επηρεάζουν την εναλλαγή των εποχών και δημιουργούν περιβαλλοντικά προβλήματα …
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[PDF] Μελετώντας την Κλιματική Αλλαγή (αίτια, επιπτώσεις, λύσεις) μέσω σύγχρονης εξ αποστάσεως εκπαίδευσης

Ε Νιάρχου - Διεθνές Συνέδριο για την Ανοικτή & εξ Αποστάσεως …, 2022
Σύμφωνα με την UNESCO," η εκπαίδευση έχει καθοριστική σημασία στο να βοηθήσει
τους πληθυσμούς να κατανοήσουν και να αντιμετωπίσουν τις επιπτώσεις της
κλιματικής αλλαγής και να ενθαρρύνουν τις αλλαγές στις στάσεις και τις …
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Το μήνυμα αυτό στάλθηκε από το Google Scholar επειδή ακολουθείτε νέα αποτελέσματα σχετικά με το θέμα ["Περιβαλλοντικά προβλήματα"].

"κλιματική αλλαγή" - νέα αποτελέσματα

[PDF] Μελετώντας την Κλιματική Αλλαγή (αίτια, επιπτώσεις, λύσεις) μέσω σύγχρονης εξ αποστάσεως εκπαίδευσης

Ε Νιάρχου - Διεθνές Συνέδριο για την Ανοικτή & εξ Αποστάσεως …, 2022
… Η παρούσα εργασία επιχειρεί να αποτυπώσει τη σύνδεση της εκπαίδευσης για την
κλιματική αλλαγή με τη σύγχρονη εξ αποστάσεως εκπαίδευση, … περιβάλλοντος με
στόχο την ευαισθητοποίηση και πληροφόρηση των μαθητών για την Κλιματική …
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Επίδραση της κλιματικής αλλαγής στην παράκτια ζώνη της λεκάνης της Μεσογείου= Climate change effects on the coastal zone of the Mediterranean basin.

ΧΑ Σκουλάκης - … Διατριβές στη Βιβλιοθήκη Θεόφραστος του Τμήματος …, 2021
… Η πιθανή κλιματική αλλαγή έχει σημαντικό αντίκτυπο στους πόρους της γης, τη
γεωγραφία, τον πληθυσμό και τις δραστηριότητες στις χώρες της Μεσογείου. Οι
συνέπειες της κλιματικής αλλαγής θα διαφέρουν ανά τόπο και μερικές φορές ανά …
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Τα δημοφιλή αποτελέσματα εμφανίζονται στο πάνω μέρος της ενότητας και τα άλλα αποτελέσματα στο κάτω μέρος.



 

[PDF] Πώς η κρίση COVID-19 μεταμόρφωσε τις δημοτικές υπηρεσίες μάθησης και εκπαίδευσης. Το παράδειγμα του Δήμου Θεσσαλονίκης.

Κ Τσινάρη, Σ Μυστακίδης - Διεθνές Συνέδριο για την Ανοικτή & εξ Αποστάσεως …, 2022
… Έτσι δημιουργήθηκε η «e-kedith experience» με δύο μεγάλες κατηγορίες
δραστηριοτήτων: Η κατηγορία «Μικροί Εξερευνητές» περιέχει διαδραστικά ψηφιακά
προγράμματα με θέμα την κλιματική αλλαγή, την ανακύκλωση, τον εκφοβισμό κ.α. Η …
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[PDF] Μικτή επιμόρφωση για τη διδασκαλία της αστρονομίας σε μικρά παιδιά: μια αρχική προσέγγιση του προγράμματος ABATAC (A Blended training Approach to Teaching …

Μ Αμπαρτζάκη, Κ Τάσσης, Μ Καλογιαννάκης… - Διεθνές Συνέδριο για την …, 2022
… Επίσης, μας βοηθούν επίσης να κατανοήσουμε τις περιβαλλοντικές επιρροές στον
χώρο, το κλίμα και την κλιματική αλλαγή. Οι βαρυτικές επιρροές από τον Ήλιο και
άλλα ουράνια σώματα είναι επίσης θεμελιώδεις για την ανάπτυξη της ζωής, καθώς και …
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[PDF] Προγράμματα Erasmus+ Βασικής Δράσης 1 του Γυμνασίου Κολυμβαρίου για μαθησιακή κινητικότητα εκπαιδευτικών: διάδοση στόχων και αποτελεσμάτων Erasmus+ …

Μ ΠΑΠΑΔΑΚΗ - Διεθνές Συνέδριο για την Ανοικτή & εξ Αποστάσεως …, 2022
Περίληψη Το Γυμνάσιο Κολυμβαρίου υλοποιεί σχέδια τα οποία αφορούν
κινητικότητες εκπαιδευτικών σε χώρες της Ευρώπης για επιμόρφωση στο πλαίσιο της
Βασικής Δράσης 1: Μαθησιακή Κινητικότητα Ατόμων-Κινητικότητα Προσωπικού …
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[PDF] Κοινότητες, ριζωματική μάθηση και μοντέλα αξιολόγησης: Μια κριτική οικοσυστημική προσέγγιση

Α Μπράιλας, Κ Παπαχριστόπουλος - Διεθνές Συνέδριο για την Ανοικτή & εξ …, 2022
κλιματική αλλαγή, μετανάστευση) εμφανίζονται στο συλλογικό επίπεδο, αφορούν
ολόκληρες κοινωνίες και κοινότητες, και σε αυτό το συνολικό επίπεδο χρειάζεται να
επιδιώκονται λύσεις (Harari, 2020, Brailas,2021b). Tα εκπαιδευτικά συστήματα …
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[PDF] Ο Ρόλος του Ψηφιακού Marketing στη διαμόρφωση Εταιρικής Εικόνας

Ε Μαρή - 2022
… Παράλληλα ο πλουραλισμός της πληροφορίας και της γνώσης, η ταχύτητα της
διάδοσης της πληροφορίας, ο υπερκαταναλωτισμός, η παγκοσμιοποίηση και κυρίως
η κλιματική αλλαγή δίνουν άλλη διάσταση στις υπερεθνικές δραστηριότητες των …
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[PDF] The four seasons: Teaching scenario for pupils of the 1st Grade of primary school in distance education

Μ Χρήστου - Διεθνές Συνέδριο για την Ανοικτή & εξ Αποστάσεως …, 2022
This text presents a teaching scenario for primary school pupils of the 1 st Grade in
the context of distance education, regarding the creative and critical approach of the
four seasons, initiated by chapter 4 of the section" Man and time" of the …
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Το μήνυμα αυτό στάλθηκε από το Google Scholar επειδή ακολουθείτε νέα αποτελέσματα σχετικά με το θέμα ["κλιματική αλλαγή"].