Παρασκευή 30 Σεπτεμβρίου 2022

"κλιματική αλλαγή" - νέα αποτελέσματα

Διερεύνηση της υπόθεσης εάν τα επιτραπέζια παιχνίδια ρόλων (Tabletop Role Playing Games) μπορούν να φανούν χρήσιμα εργαλεία στην περιβαλλοντική εκπαίδευση …

ΕΠ Κουρουμιχάκη - 2022
… Αυτή η επιλογή εδράζεται στην πεποίθηση ότι μέσα στο συγκείμενο της σημερινής
κοινωνικοϊστορικής πραγματικότητας που η κλιματική αλλαγή, έχει μετατραπεί σε
κλιματική κρίση, η σημασία της «Εκπαίδευσης για την Αειφορία», γίνεται καταλυτική …
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Επάνω εμφανίζονται τα πιο συναφή αποτελέσματα και κάτω τα λιγότερο συναφή αποτελέσματα



 

[PDF] Βιώσιμη ανάπτυξη στην παραγωγή ηλεκτρικής ενέργειας μέσω καινοτόμων τεχνολογιών

Κ Δαβανέλος - 2022
… Η κλιματική αλλαγή έχει άμεση σχέση με τις συγκεντρώσεις διοξειδίου του άνθρακα.
Η ποσότητα του CO2 στην ατμόσφαιρα έχει αυξηθεί μαζί με την κατανάλωση
ενέργειας από ορυκτά καύσιμα και επιταχύνθηκε από τη Βιομηχανική Επανάσταση …
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[PDF] Προγράμματα φιλαναγνωσίας στις Δημοτικές Βιβλιοθήκες

ΚΆ Στεφάνσκα - 2022
… Εκτός από αυτά, γίνονται διαλέξεις για θέματα που αφορούν το περιβάλλον και την
κλιματική αλλαγή όπου οι συμμετέχοντες ενημερώνονται για τους τρόπους με τους
οποίους μπορούν να προστατεύσουν τον πλανήτη και να τον βοηθήσουν να …
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Ασφάλεια Διαστήματος: Η Περίπτωση της Ελλάδας

Σ Τσώνης - 2022
… Έτσι, απειλές όπως η τρομοκρατία, η μετανάστευση και το προσφυγικό, η
κλιματική αλλαγή, η ενεργειακή ασφάλεια κ.α. εξετάζονται πολύπλευρα, πράγμα που
σημαίνει ότι πολλές απειλές συσχετίζονται έμμεσα ή/και άμεσα. Παραδείγματος χάριν …
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Το μήνυμα αυτό στάλθηκε από το Google Scholar επειδή ακολουθείτε νέα αποτελέσματα σχετικά με το θέμα ["κλιματική αλλαγή"].

intitle:"environmental disasters" - νέα αποτελέσματα

[PDF] Environmental, Natural and Man-Made Disasters Reflected in Kazakh Eco-Documentary Films

Б Абдыкасымов, А Машурова - Central Asian Journal of Art Studies, 2022
… The young generation of documentary filmmakers has also not been left out and
continues this tradition of highlighting the Aral Sea and the terrible consequences to
show the world about the existing environmental disasters. One of the worthy films …
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Το μήνυμα αυτό στάλθηκε από το Google Scholar επειδή ακολουθείτε νέα αποτελέσματα σχετικά με το θέμα [intitle:"environmental disasters"].

"Περιβαλλοντικά προβλήματα" - νέα αποτελέσματα

[PDF] Βιώσιμη ανάπτυξη στην παραγωγή ηλεκτρικής ενέργειας μέσω καινοτόμων τεχνολογιών

Κ Δαβανέλος - 2022
… ηλεκτρικής ενέργειας στην περιοχή τους γινόταν από ΑΠΕ, τα περιβαλλοντικά
προβλήματα θα μειωνόταν. Όπως προκύπτει από τα στοιχεία στον … Θεωρείτε ότι αν
η παραγωγή ηλεκτρικής ενέργειας στην περιοχή σας γινόταν από ΑΠΕ, τα …
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Το μήνυμα αυτό στάλθηκε από το Google Scholar επειδή ακολουθείτε νέα αποτελέσματα σχετικά με το θέμα ["Περιβαλλοντικά προβλήματα"].

Πέμπτη 29 Σεπτεμβρίου 2022

Long-term Locoregional Control With Unilateral Radiation for AJCC-7 T1-2N2b Tonsillar Cancer

alexandrossfakianakis shared this article with you from Inoreader
imageObjectives: Unilateral radiation to cervical nodes has been used as a de-escalation strategy in well-lateralized tonsil cancers. The efficacy of this approach with multiple ipsilateral nodes is not established. The study hypothesis was that unilateral radiation for American Joint Committee on Cancer (AJCC)-7 T1-2N2b tonsillar cancer results in a low rate of contralateral nodal failure. Materials and Methods: This study was a retrospective chart review of patients with AJCC-7 T1-2N2b tonsillar cancer from 2 academic institutions who were treated with unilateral radiation. The primary endpoint was the contralateral nodal failure rate. Locoregional control, overall survival, and the need for gastrostomy tube placement were additional endpoints. Results: The study cohort included 66 patients treated between 2005 and 2016. The median follow-up time was 80.9 months; contralateral nodal failure occurred in 2/66 (3.0%) patients at 4.1 and 20.9 months, respectively. Both patients underwent salvage treatment with long-term subsequent survival. Overall locoregional control at both 2 and 5 years was 93.9% and the median duration of control was not reached. Overall survival at 5 years was 92.4%. Conclusions: The use of unilateral radiation for AJCC-7 T1-2N2b tonsillar cancer resulted in low rates of contralateral nodal failure. This outcome demonstrates the safety of considering unilateral radiation treatment in patients with a relatively high ipsilateral nodal burden.
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Controlling Nutritional Status (CONUT) score is a prognostic marker for laryngeal cancer patients with curative resection

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Background

To investigate the prognostic value of pre-treatment Controlling Nutritional Status (CONUT) score in laryngeal cancer.

Methods

Preoperative CONUT score was retrospectively calculated in 154 laryngeal cancer patients who underwent curative resection in our hospital from 2013 to 2016. The associations of CONUT with clinicopathological factors and survival were evaluated. The efficacy of CONUT score to predict prognosis was evaluated.

Results

The CONUT score was associated with body mass index (p = 0.033), neutrophil (p = 0.011), tumor size (p = 0.017), pTNM stage (p = 0.001), adjuvant radiotherapy (p < 0.001), negative pathologic factors (p < 0.001), and larynx preservation (p < 0.001). Patients with a higher CONUT score had worse overall survival (hazard ratio: 1.94, 95% confidence interval [CI]: 1.13–3.72, p = 0.039) and disease-free survival (hazard ratio: 2.16, 95% CI: 1.19–3.90, p = 0.011). The area under the curve of CONUT score (0.728) was higher than Preoperative Nutritional Index (0.72), platelet-to-lymphocyte ratio (0.675), and neutrophil-to-lymphocyte ratio (0.687).

Conclusion

The CONUT score can be useful for predicting survival in laryngeal cancer patients after curative resection.

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Τετάρτη 28 Σεπτεμβρίου 2022

Evaluation of an Opt-Out Protocol for Antibiotic De-escalation in Patients with Suspected Sepsis: a multicenter randomized controlled trial

alexandrossfakianakis shared this article with you from Inoreader

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Abstract
Background
Sepsis guidelines recommend daily review to de-escalate or stop antibiotics in appropriate patients. This randomized controlled trial evaluated an opt-out protocol to decrease unnecessary antibiotics in patients with suspected sepsis.
Methods
We evaluated non-ICU adults on broad-spectrum antibiotics despite negative blood cultures at ten U.S. hospitals from September 2018 through May 2020. A 23-item safety check excluded patients with ongoing signs of systemic infection, concerning or inadequate microbiologic data, or high-risk conditions. Eligible patients were randomized to the opt-out protocol vs. usual care. The primary outcome was 30-day post-enrollment antibacterial days of therapy (DOT). Clinicians caring for intervention patients were contacted to encourage antibiotic discontinuation using opt-out language. If antibiotics were continued, clinicians discussed rationale for continuing antibiotics and de-escalation plans. To evaluate those with zero post-enrollment DOT, hurdle models provided two measures: 1) the odds ratio of antibiotic continuation and 2) ratio of mean DOT among those who continued antibiotics.
Results
Among 9606 patients screened, 767 (8%) were enrolled. Intervention patients had 32% lower odds of antibiotic continuation (79% vs. 84%, OR 0.68, 95% confidence interval (CI) [0.47, 0.98]). DOT among those who continued antibiotics were similar (ratio of means 1.06, 95% CI [0.88-1.26]). Few er intervention patients were exposed to extended-spectrum antibiotics (36% v. 44%. Common reasons for continuing antibiotics were treatment of localized infection (76%) and belief that stopping antibiotics was unsafe (31%). Thirty-day safety events were similar.
Conclusions
An antibiotic opt-out protocol targeting patients with suspected sepsis resulted in more antibiotic discontinuations, similar DOT when antibiotics were continued, and no evidence of harm.
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Efficacy of bismuth for antibiotic‐resistant Helicobacter pylori strains eradication: A systematic review and meta‐analysis

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Abstract

Background & Aims

Antibiotic resistance of Helicobacter pylori (H. pylori) is increasing worldwide, and bismuth quadruple therapy has been recommended as a first-line regimen in many areas. This study aimed to investigate whether bismuth would improve the eradication rate (ER) of clarithromycin-/metronidazole-/levofloxacin-resistant H. pylori strains and how much additional efficacy bismuth could achieve.

Methods

PubMed, EMBASE, Web of Science, and Cochrane Central databases for randomized controlled trials were systematically searched by two independent reviewers until 15 January 2022. Pooled ERs of clarithromycin-/metronidazole-/levofloxacin-resistant H. pylori strains were compared between bismuth-containing and non-bismuth therapies. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model.

Results

Eight studies enrolling 340 individuals were included. The RRs of pooled ERs compared between bismuth-containing and non-bismuth therapies were 1.83 for clarithromycin-resistant strains (95% CI 1.16–2.89, pooled ER: 76.9% vs. 36.6%, p = .009, I2 = 0%), 1.39 for metronidazole-resistant strains (95% CI 1.09–1.78, pooled ER: 86.8% vs. 60.9%, p = .008, I2 = 37%), 2.75 for dual clarithromycin/metronidazole-resistant strains (95% CI 1.01–7.52, pooled ER: 76.9% vs. 18.2%, p = .05, I2 = 0%), and 1.04 for levofloxacin-resistant strains (95% CI 0.56–1.93, pooled ER: 63.4% vs. 54.3%, p = .90; I2 = 60%). Bismuth significantly increased the ERs of clarithromycin-, metronidazole-, and dual-resistant strains by 40%, 26%, and 59%, respectively. Subgroup analysis of treatment duration showed that the significantly higher eradication rate fo r antibiotic-resistant strains in bismuth-containing therapy than non-bismuth therapy was only observed in 14-day treatment regimens and not in 7-day regimens (p = .02 and .17, respectively).

Conclusions

Bismuth was most effective in improving the ERs of dual-resistant H. pylori strains, followed by clarithromycin- and metronidazole-resistant strains. Prolonged treatment duration might effectively improve the efficacy of bismuth in overcoming antibiotic resistance.

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Prolonged neutropenia is a risk of oral adverse events-related sepsis but is not associated with prognosis of tooth extraction in hematopoietic stem cell transplant recipients: a retrospective study

alexandrossfakianakis shared this article with you from Inoreader

Publication date: Available online 27 September 2022

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Yasuyuki Shimada, Yuki Shiko, Akira Hangaishi, Yohei Kawasaki, Yutaka Maruoka

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Bone characteristics in condylar hyperplasia of the temporomandibular joint: a microcomputed tomography, histology, and Raman microspectrometry study

alexandrossfakianakis shared this article with you from Inoreader
Unilateral condylar hyperplasia (UCH) of the temporomandibular joint is a progressive deformation of the mandibular condyle of unknown origin. UCH is characterized by excessive growth of the condylar head and neck, leading to an increase in size and volume. The aim of this study was to investigate the characteristics of the bone in patients with UCH using microcomputed tomography (micro-CT), histology, and Raman microspectroscopy. The mandibular condyles of six patients with UCH were analysed using micro-CT, histology, and Raman microspectrometry and imaging, and the results were compared with those obtained for a normal control subject. (Source: International Journal of Oral and Maxillofacial Surgery)
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Pterygoid muscle activity in speech: a preliminary investigation

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Background

Speaking depends on refined control of jaw opening and closing movements. The medial pterygoid muscle (MPT), involved in jaw closing, and the lateral pterygoid muscle (LPT), involved in jaw opening, are two key mandibular muscles in mastication and are likely to be recruited for controlled movements in speech.

Objectives

Three hypotheses were investigated, that during speech the MPT and LPT: (1) are both active, (2) but exhibit different patterns of activity, (3) which fluctuate with the vowels and consonants in speech.

Methods

Intramuscular EMG recordings were made from the right inferior head of the LPT and/or the right MPT in five participants during production of 40 target nonsense words (NWs) consisting of three syllables in the form /V1 C 1 V 2 C2ə/ (V = vowel; C = consonant; ə = unstressed, reduced vowel), spoken by each participant 10 times per NW; analysis focussed on the target syllable, C 1 V 2 .

Results

Both MPT and LPT exhibited robust increases in EMG activity during utterance of most NWs, relative to rest. Peak LPT activation was time-locked to the final part of the target consonant (C1) interval when the jaw begins opening for the target vowel (V2), whereas peak MPT activation occurred around the temporal midpoint of V2, when the jaw begins closing for C2. EMG amplitude peaks differed in magnitude between "high" vowels, i.e., for which the tongue/jaw are high (e.g., in S EE K), and "low" vowels, i.e., for which the tongue/jaw are low (e.g., in S O CK).

Conclusion

These novel findings suggest a key role for the LPT and MPT in the fine control of speech production. They imply that speech may impose major synergistic demands on the activities of the MPT and the LPT, and thereby provide insights into the possible interactions between speech activities and orofacial activities (e.g. mastication) and conditions (e.g. Temporomandibular Disorders) that involve the masticatory muscles.

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