Spotlight on microRNAs in allergy and asthma

gnorimies2015 shared this article with you from Inoreader Spotlight on microRNAs in allergy and asthma Via Allergy Abstract In past ten years, microRNAs (miRNAs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases and theirpotential as biomarkersin liquid biopsies. They act as master post‐transcriptional regulators that control most cellular processes. As one miRNA can target several mRNAs, often within the same pathway, dysregulated expression of miRNAs may alter particular cellular responses and contribute, or lead, to the development of various diseases.In this review, we give an overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis and asthma. Specifically, we discuss howindividualmiRNAs function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses. In addition, we review insightsobtained fromexperiments with murine models of allergic airway and skin inflammation andoffer an overview of s tudiesfocusing on miRNA discovery using profiling techniques and bioinformatic modelling of the network effect of multiple miRNAs. In conclusion, we highlight the importance of research intomiRNA function in allergy and asthma to improve our knowledge of the molecular mechanisms involved in the pathogenesis of this heterogeneousgroup of diseases. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Non‐invasive and minimally‐invasive techniques for the diagnosis and management of allergic diseases

gnorimies2015 shared this article with you from Inoreader Non‐invasive and minimally‐invasive techniques for the diagnosis and management of allergic diseases Via Allergy Abstract Allergic diseases of the (upper and lower) airways, the skin as well as the gastrointestinal tract, are on the rise, resulting in impaired quality of life, decreased productivity and increased healthcare costs. As allergic diseases are mostly tissue specific, local sampling methods for respective biomarkers offer the potential for increased sensitivity and specificity. Additionally, local sampling using non‐invasive or minimally‐invasive methods can be cost‐effective and well tolerated, which may even be suitable for primary or home care sampling. Non‐ or minimally‐invasive local sampling and diagnostics may enable a more thorough endotyping, may help to avoid under‐ or overdiagnosis, and may provide the possibility to approach precision prevention, due to early diagnosis of these local diseases even before they get systemically manifested and detectable. At the same time, dried blood samples may help to facilitate minimal‐invasive primary or home care sampling for classical systemic diagnostic approaches. This EAACI position paper contains a thorough review of the various technologies in allergy diagnosis available on the market, which analytes or biomarkers are employed, and which samples or matrices can be used. Based on this assessment, EAACIs position is to drive these developments to efficiently identify allergy and possibly later also viral epidemics and take advantage of comprehensive knowledge to initiate preventions and treatments. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Improvement of oral hypofunction by a comprehensive oral and physical exercise program including textured lunch gatherings

gnorimies2015 shared this article with you from Inoreader Improvement of oral hypofunction by a comprehensive oral and physical exercise program including textured lunch gatherings Via Journal of Oral Rehabilitation Abstract Background The deterioration of oral function to a state of oral hypofunction (OHF) is reportedly associated with malnutrition and frailty. Objective Investigate the association of OHF with physical characteristics and function and test the effects of a program including comprehensive oral and physical exercises and textured lunch gatherings (COPE‐TeL program) on oral and physical function in older adults with OHF. Materials and Methods Eighty‐six community‐dwelling older adults were randomly assigned into control (n = 43) or intervention (n = 43) groups. The participants were further divided into OHF and normal oral function (NOF) sub‐groups based on initial oral examinations. The intervention group participated in the 12‐week COPE‐TeL program, while the control group performed the physical exercise regimen only. The differences in measured variables for physical and oral function between the OHF and NOF groups were statistically tested, and changes in the proportion of participants with OHF were examined. Results Physical function, such as hand grip strength and walking speed, was significantly lower in the OHF group at the initial assessment. The proportion of participants with OHF was 56% in the intervention group and 67% in the control group before the trial, which became significantly reduced after completing the COPE‐TeL program in the intervention group (26%, P = 0.002), but not in the controls (61%, P = 0.549). Conclusion Older adults with OHF may have diminished physical function. The COPE‐TeL program of oral and physical exercises along with textured lunch gatherings may be effective for older adults with OHF. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Principles, potential and limitations of ex vivo basophil activation by flow cytometry in allergology: a narrative review.

gnorimies2015 shared this article with you from Inoreader Principles, potential and limitations of ex vivo basophil activation by flow cytometry in allergology: a narrative review. Via Journal of Allergy and Clinical Immunology The major challenge of allergy diagnosis lies in the development of accessible and reliable diagnostics allowing correct prediction of the clinical outcome upon exposure to the offending allergen(s) and cross-reactive structures. Since the late nineties, evidence has accumulated that flow-assisted analysis and quantification of ex vivo activated basophils (BAT) might meet this requirement for different IgE-dependent allergies and particular forms of auto-immune urticaria. Other, so called non-diagnostic applications of the BAT involve therapeutic monitoring, follow-up of natural histories and identification of allergenic recognition sites. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy.

Cancer shared this article with you from Inoreader Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy. Via Breast Cancer CONCLUSIONS: The plasma levels of docetaxel were significantly influenced by the SNP C1236T of ABCB1 gene coding for the MDR1 transporter (P-glycoprotein). The plasma levels of docetaxel were also found to influence its therapeutic effect. PMID: 33125673 [PubMed - as supplied by publisher] (Source: Breast Cancer) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Skin grafting utilizing a skin of lateral thoracic area for chest wall reconstruction in patient who underwent mastectomy for locally advanced breast cancer.

Cancer shared this article with you from Inoreader Skin grafting utilizing a skin of lateral thoracic area for chest wall reconstruction in patient who underwent mastectomy for locally advanced breast cancer. Via Breast Cancer Authors: Sakamoto N, Nashimoto M, Nakagawa M, Haruyama Y, Koshida Y, Fukuma E Abstract Locally advanced breast cancer sometimes results in a large chest wall defect at mastectomy. When closing the wound horizontally, the skin tension is usually severe in the middle of the wound, while the skin of the lateral area tends to make a dog-ear deformity. Triangle technique is a procedure to prevent the dog ear in which the skin and subcutaneous fat of the axilla are cut into an equilateral triangle. Herein, we present a case of breast cancer who underwent a mastectomy and closed the wound with a skin graft by utilizing the skin removed from lateral thoracic area using triangle technique. An 85-year-old female visited our institution complaining about the mass on her right breast. Preopera... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Beyond bevacizumab: a review of targeted agents in metastatic small bowel adenocarcinoma

Cancer shared this article with you from Inoreader Beyond bevacizumab: a review of targeted agents in metastatic small bowel adenocarcinoma Via Latest Results for Medical Oncology Abstract Small bowel cancers are rare tumors with an incidence 50–100-fold less than colorectal cancer. These tumors carry a poor prognosis. Owing to its rarity, treatment of this disease, particularly in its advanced stages, has not been optimized and is derived mainly from treatment regimens for colorectal cancer. Based on recent studies bevacizumab, an antibody directed against vascular endothelial growth factor and used in the management of metastatic CRC, has been added to treatment guidelines for metastatic small bowel adenocarcinoma. We investigate in this review the evidence behind other targeted treatments that may be beneficial in the treatment of metastatic small bowel adenocarcinoma. These are agents against EGFR, VEGFR-2, HER2, and NTRK as well as immune checkpoint inhibitors. The last class of drugs appears to hold the greatest promise based on the preponderance of evidence supporting its use. However, overall data remains sparse. Results of studies curr ently underway will be valuable in shedding more light on the management of this aggressive cancer. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.