We read with interest the recent article by Nissen et al,1 which described a possible association of sinonasal adenocarcinoma with occupational exposure to styrene in the production of glass-reinforced plastics. Noting the limited statistical significance of their finding, and the potential for uncontrolled residual confounding by occupational exposure to wood dust, the authors called for further studies to confirm or refute the hazard.
During the 1980s we assembled a cohort of 7970 workers exposed to styrene in the British glass-reinforced plastics industry.2 Our cohort included 3488 laminators with exposures to styrene in the order of 40–100 parts per million (ppm), in many cases for a year or longer. We extended our follow-up of this cohort at the end of 2012.3 In response to the call from Nissen and colleagues1 for more studies, we have revisited our analysis of the most recent follow-up, examining mortality...
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