IJERPH, Vol. 14, Pages 1282: Endocrine Disruptors Leading to Obesity and Related Diseases

IJERPH, Vol. 14, Pages 1282: Endocrine Disruptors Leading to Obesity and Related Diseases

International Journal of Environmental Research and Public Health doi: 10.3390/ijerph14101282

Authors: Demetrios Petrakis Loukia Vassilopoulou Charalampos Mamoulakis Christos Psycharakis Aliki Anifantaki Stavros Sifakis Anca Docea John Tsiaoussis Antonios Makrigiannakis Aristides Tsatsakis

The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

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